Hybrid polymer micelles capable of cRGD targeting and pH-triggered surface charge conversion for tumor selective accumulation and promoted uptake.
نویسندگان
چکیده
This study presents both tumor-targeting ligands (cRGD) and pH-activated surface charge-conversional moiety (imidazole) decorated micelles for Dox delivery. cRGD is expected to induce preferential tumor accumulation, while imidazole switches on positive charge in a tumor acid environment, which leads to enhanced micelle uptake by tumor cells.
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عنوان ژورنال:
- Chemical communications
دوره 50 65 شماره
صفحات -
تاریخ انتشار 2014